Anastomosing strands of basaloid cells lend the characteristic appearance of this tumor.
The edge of the strands show peripheral pallisading of nuclei.
This different cases demonstrates both delicate cords and more solid growth. It resembles seborrheic keratosis.
Note the multiple connections to the epithelium.
This different example demonstrates again the reticulated anastomosing cords of basaloid cells.
Fibroepithelioma of Pinkus is considered an indolent histologically distinct variant of basal cell carcinoma. Histologically, it is characterized by anastomosing cords of basaloid cells, forming a reticulated, delicate, almost lace-like network. The tumor connects with the overlying epithelium at multiple points (Busam, Crowson). The stroma can be mxyoid, loose or fibrotic.
Clinically, this is a benign-appearing, pedunculated, pink or flesh-colored nodule that may resemble an acrochordon (skin tag). Unlike the other histologic types of basal cell carcinoma which generally arise on sun-exposed skin (especially face), fibroepithelioma of Pinkus usually arises on the trunk and extremities. Usually affects adults 40-60, but have been described in children (Mehregan).
Busam KJ. Dermatopathology: Foundations in Diagnostic Pathology 1st Ed. Philadelphia, PA: Elsevier; 2010: 389-397.
Crowson AN. Basal cell carcinoma: biology, morphology and clinical implications. Modern Pathology (2006) 19, S127-S147.
Mehregan D. Premalignant Fibroepithelial Tumor (Pinkus Tumor): eMedicine. Last updated on Jan 24 2012. Available at: emedicine.medscape.com/article/1101357
Rapini RP.Practical Dermatopathology. Philadelphia, PA: Elsevier; 2005: 249-252.