The surface of the neoplastic mucosa shows papillary infoldings.
Prominent clear cells with abundant cytoplasm, arranged in trabeculae with a festoon (draping garland) quality.
Prominent cytoplasmic borders lends a histologic picture that mimics RCC.
Clear cell adenocarcinoma of the gallbladder is a variant of gallbladder adenocarcinoma composed of glycogen-rich (optically clear) cells. In most instances, areas of typical adenocarcinoma are seen as well. It is important to distinguish this variant from metastatic renal cell carcinoma.