Fundic/body gastric biopsy shows glandular drop-out, intestinal metaplasia and nests of cells resembling neuroendorine cells.

52 year old with weakness with anemia undergoes upper endoscopy.

Atrophic gastritis can be related to chronic H. pylori or due to anti-parietal cell or anti-intrinsic factor antibodies.

Lowered acid secretion leads to increased gastrin from the antral G cells, which then stimulates enterochromaffin-like (ECL) cells within the body and can lead to ECL cell hyperplasia. ECL cell hyperplasia progresses from normal, simple hyperplasia, linear hyperplasia, nodular hyperplasia, and beyond. Stomach : Atrophic Gastritis