Path Image

The squamous mucosa appears intact but is undermined by numerous red cells and a spindle cell lesion.

The neoplasm consists of numerous vascular spaces that are anastomosing. There is no intervening normal stroma.

Vascular spaces are lined by plump atypical endothelial cells with vesicular nuclei.


Angiosarcomas are rare sarcomas vascular endothelium. In the head and nec region, the scalp is the most common site of origin. Less than 4% of all angiosarcomas occur in the pharynx, oral cavity and nasal sinuses (1).


Due to its rarity, there is minimal published information regarding response to

treatment and prognosis at this site. In one series of head and neck angiosarcomas, overall

5-year survival was 33% (Lydiatt). Tumor size and resectability were important predictors.


1 Enzinger FM, Weiss SW. Soft Tissue Tumours, 3rd edn. St Louis: C.V. Mosby Company, 1995:641–77

Lydiatt WM, Shaha AR, Shah JP. Angiosarcoma of the head and neck. Am J Surg 1994;168:451–4

Last updated: 2010-02-25
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