Path Image
Mature ganglion cells seen in a neuroblastoma post-chemotherapy.

Post-chemotherapy maturation is seen, which includes the presence of mature ganglion cells. Note also, the presence of hemosiderin-laden macrophages.

Dystrophic calcifications and multinucleated giant cells are set in background of loose spindled stroma indicative of tumor regression.

The Schwannian stroma consists of organized fascicles of spindle cells that resemble mature Schwann cells. Again, maturation includes both the presence of mature ganglion cells and Schwannian stroma.

Clusters of ganglion cells can be appreciated.


Neuroblastomas may spontaneously regress (which mostly occurs in infants) or mature. Maturation may be induced by chemotherapy, as demonstrated in this case.

Last updated: 2011-03-02
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