Path Image

Numerous small to medium sized cystic spaces are present in a dense lymphoid stroma.

The cystic spaces are lined by bland sebaceous epithelium. One of the lumens contains a little secretions. Keratin filled cysts may also be encountered.


It has been recognized, since first reported in 1931, that there are areas of sebaceous differentiation in normal parotid and other salivary tissue in about 25% of individuals1,2 . These regions are very seldom involved in tumors affecting the gland and only about thirty sebaceous lymphadenoma(SL) cases have been reported in the literature7 . Other neoplasms affecting subaceous tissue in the salivary glands include sebaceous carcinoma, sebaceous adenoma and sebaceous lymphadenocarcinoma.


Mostly diagnosed in the 6-8th decades, the vast majority(>90%) of these arise in the parotid gland and in immediately adjacent tissues. This tumor has been reported to affect minor salivary glands as well3 . Patient presentation typically includes a slow growing and painless mass present for months to years3,4 . Several cases of sebaceous lymphadenoma have been reported associated with Warthins tumor. It has been hypothesized that SL represents subaceous metaplasia of a component of a Warthins tumor5 . Other authors note no such connection6 .


Treatment is local excision with negative margins.


With complete excision, the long term prognosis is excellent for this benign tumor.


1 Hamperl H. Beitrage zur normalen und pathologischen Histologie menschlicher Speicheldrusen. Z Mikrosk Anat Forsch 1931;27:1-55.

2 Meza-Chavez L. Sebaceous glands in normal and neoplastic parotid glands possible significance of sebaceous glands in respect to the origin of the tumours of the salivary glands. Am J Pathol 1949;25:627-45.

3 Kurokawa H, Murata T, Fukuyama H, Kajiyama M. Sebaceous lymphadenoma in the midline of the maxilla: report of case. J Oral Maxillofac Surg 1999;57:1461-3.

4 Maruyama S, Cheng J, Inoue T, Takagi R, Saku T. Sebaceous lymphadenoma of the lip: report of a case of minor salivary gland origin. J Oral Pathol Med 2002;31:242-3.

5 Merwin WH Jr, Barnes L, Myers EN . Unilocular cystic sebaceous lymphadenoma of the parotid gland. Arch Otolaryngol 1985;111:273-5.

6 Linhartova A. Sebaceous glands in salivary gland tissue. Arch Pathol 1974;98:320-4.

7 Maffini F, Fasani R, Petrella D, Maiorano E, Bruschini R, Pelosi G, Viale .Sebaceous lymphadenoma of salivary gland: a case report and a review of the literature. Acta Otorhinolaryngol Ital. 2007 Jun;27(3):147-50.

Last updated: 2010-10-03
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