Numerous small to medium sized cystic spaces are present in a dense lymphoid stroma.
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The cystic spaces are lined by bland sebaceous epithelium. One of the lumens contains a little secretions. Keratin filled cysts may also be encountered.
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It has been recognized, since first reported in 1931, that there are areas of sebaceous differentiation in normal parotid and other salivary tissue in about 25% of individuals1,2 . These regions are very seldom involved in tumors affecting the gland and only about thirty sebaceous lymphadenoma(SL) cases have been reported in the literature7 . Other neoplasms affecting subaceous tissue in the salivary glands include sebaceous carcinoma, sebaceous adenoma and sebaceous lymphadenocarcinoma.
Mostly diagnosed in the 6-8th decades, the vast majority(>90%) of these arise in the parotid gland and in immediately adjacent tissues. This tumor has been reported to affect minor salivary glands as well3 . Patient presentation typically includes a slow growing and painless mass present for months to years3,4 . Several cases of sebaceous lymphadenoma have been reported associated with Warthins tumor. It has been hypothesized that SL represents subaceous metaplasia of a component of a Warthins tumor5 . Other authors note no such connection6 .
Treatment is local excision with negative margins.
With complete excision, the long term prognosis is excellent for this benign tumor.
1 Hamperl H. Beitrage zur normalen und pathologischen Histologie menschlicher Speicheldrusen. Z Mikrosk Anat Forsch 1931;27:1-55.
2 Meza-Chavez L. Sebaceous glands in normal and neoplastic parotid glands possible significance of sebaceous glands in respect to the origin of the tumours of the salivary glands. Am J Pathol 1949;25:627-45.
3 Kurokawa H, Murata T, Fukuyama H, Kajiyama M. Sebaceous lymphadenoma in the midline of the maxilla: report of case. J Oral Maxillofac Surg 1999;57:1461-3.
4 Maruyama S, Cheng J, Inoue T, Takagi R, Saku T. Sebaceous lymphadenoma of the lip: report of a case of minor salivary gland origin. J Oral Pathol Med 2002;31:242-3.
5 Merwin WH Jr, Barnes L, Myers EN . Unilocular cystic sebaceous lymphadenoma of the parotid gland. Arch Otolaryngol 1985;111:273-5.
6 Linhartova A. Sebaceous glands in salivary gland tissue. Arch Pathol 1974;98:320-4.
7 Maffini F, Fasani R, Petrella D, Maiorano E, Bruschini R, Pelosi G, Viale .Sebaceous lymphadenoma of salivary gland: a case report and a review of the literature. Acta Otorhinolaryngol Ital. 2007 Jun;27(3):147-50.