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A cytologically bland exophytic papillary lesion with minimal keratinization composes the lesion.

The multilayered squamous epithelium is affected by some chronic inflammation and reactive atypia. Basal cell hyperplasia is mild but apparent.


Squamous papilloma of the oral cavity is an HPV-driven lesion, most often related to HPV types 6 and 11.


Lesions may arise in children as well as adults. Any site in the oral cavity may be affected although as in this case, the palate is a favored place for them to arise. A soft pedunculated nodule, which may appear granular due to the papillary fronds, and usually under 1 cm, is observed.


Excision or laser ablation.


Benign, with very rare recurrences.

Last updated: 2010-03-23
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