Gastric glands lined by foveolar epithelium with intestinal metaplasia are seen immersed within a cellular background of lymphoid cells.
){kind=link}
Reactive foveolar glands merge with a malignant proliferation of enlarged cells surrounded by a mature lymphoid stroma.
){kind=link}
Tumor cells consist of sheets of cells without any glandular differentiation.
){kind=link}
The malignant cells are large with vesicular chromatin and uniformly large nucleoli; a chronic inflammatory infiltrate is intimately admixed.
){kind=link}
Epstein–Barr virus-associated gastric carcinoma is defined as the presence of EBV in the tumor cells, which is identified by performing EBV-encoded RNA (EBER) in situ hybridization. A low power of the underlying infiltrating component for EBER is seen here. The mature appearing lymphoid cells are EBER negative while the enlarged cells are staining.
){kind=link}
The normal glands are negative for EBER but the tumor cells are markedly positive.
){kind=link}
Lymphoepithelioma-like gastric carcinomas associated with EBV show a male predominance(Shibata).
There remains controversy with respect to the effects of EBV-related gastric cancer on survival. van Beek et al. reported that these tumors are significantly associated with better cancer-specific survival and a longer disease-free period (van Beek). Other studies fail to show any relationship between survival and EBV related tumors, as compared with EBV-negative gastric cancers (Kume; Chang).
• Cervix : Lymphoepithelial-like Carcinoma
Herath CH, Chetty R. Epstein-Barr virus-associated lymphoepithelioma-like gastric carcinoma. Arch Pathol Lab Med. 2008 Apr;132(4):706-9.
Shibata, D. , M. Tokunaga , Y. Uemura , E. Sato , S. Tanaka , and L. M. Weiss . Association of Epstein-Barr virus with undifferentiated gastric carcinomas with intense lymphoid infiltration, lymphoepithelioma-like carcinoma. Am J Pathol 1991. 139:469–474.
Van Beek J, Zur Hausen A, Klein Kranenbarg E et al. EBV-positive gastric adenocarcinomas: a distinct clinicopathologic entity with a low frequency of lymph node involvement. J. Clin. Oncol. 2004; 22: 664–70.
Kume T, Oshima K, Shinohara T et al. Low rate of apoptosis and overexpression of bcl-2 in Epstein-Barr virus-associated gastric carcinoma. Histopathology 1999; 34: 502–9.
Chang MS, Lee HS, Kim CW, Kim YI, Kim WH. Clinicopathologic characteristics of Epstein-Barr virus-incorporated gastric cancers in Korea. Pathol. Res. Pract. 2001; 197: 395–400.