Liver biopsy shows infiltration of metastatic glands.
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CASE BACKGROUND
60 year old male with liver biopsy.
METASTATIC ADENOCARCINOMA, FAVOR LOWER GI TRACT
The metastatic glands are moderately differentiated. The possibilities for a primary tumor include GI tract, pancreatobiliary and lung. CDX2 is a marker for gastrointestinal differentiation and was positive. The CK7- and CK20+ immunoprofile favors a lower GI origin and less likely a pancreatobiliary origin (which would be CK7+ and CK20-). Of note, but not shown TTF-1 was negative, thus, a lung adenocarcinoma is less likely.
RELATED CASES/FURTHER READING
Colon : Adenocarcinoma, Conventional TypeFor questions, comments or feedback on this case: editor@surgpath4u.com